購物車
幫助
021-54845833/15800441009
中文名稱： 兔抗SHC1多克隆抗體
英文名稱： Anti-SHC1 rabbit polyclonal antibody
別 名： SHC adaptor protein 1; SHC; SHCA
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： SHC1
反應(yīng)種屬： Human, Mouse, Rat
標記物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
|
Background: |
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. |
|
Applications: |
ELISA, WB, IHC |
|
Name of antibody: |
SHC1 |
|
Immunogen: |
Fusion protein of human SHC1 |
|
Full name: |
SHC adaptor protein 1 |
|
Synonyms: |
SHC; SHCA |
|
SwissProt: |
P29353 |
|
ELISA Recommended dilution: |
5000-10000 |
|
IHC positive control: |
Human cervical cancer |
|
IHC Recommend dilution: |
25-100 |
|
WB Predicted band size: |
63 kDa |
|
WB Positive control: |
Hela, HepG2, NIH/3T3, 293T, Jurkat, RAW264.7 and 231 cell lysates |
|
WB Recommended dilution: |
200-1000 |
